Denver (12-3) pulled into a tie for first place in the AFC with Houston, which fell 23-6 to the Vikings.
Manning finished with 339 yards on 30-for-43 passing. Von Miller was in on two sacks for the Broncos, the second of which knocked Browns quarterback Brandon Weeden out of the game with a right shoulder injury.
Miller has 17 ½ sacks on the season, breaking Elvis Dumervil’s franchise record.
If Denver defeats Kansas City at home next week and Houston loses at Indianapolis, the Broncos would be the AFC’s top seed.