Events will be held Saturday and Sunday at the park, which is southeast of Fairbury in Jefferson County.
The station was established in 1857 along the Oregon and California trails. It was a supply center and resting spot for westward pioneers and later became a Pony Express relay station.
Activities will include black powder gun demonstrations, cowboy action shooting, wagon rides and demonstrations of several period trades.
There will be a free-will donation lunch on Saturday and a buffalo stew cookout Saturday at 7 p.m.
Tickets must be purchased in advance. They cost $9 for adults and $6 for ages 13 and under. Call the park at 402-729-5777.