Peppers was expected to play Thursday night against San Diego, but the Bears held him out again after he sat out the preseason opener against Carolina. Peppers has been limited in practice for about two weeks.
The Bears also held out defensive tackle Henry Melton (concussion), receiver Earl Bennett (concussion), right tackle Jonathan Scott (right knee), long snapper Patrick Mannelly (rib), running back Armando Allen (hamstring) and linebacker D.J. Williams (strained right calf).
The Chargers held out running back Danny Woodhead (undisclosed injury), receiver Malcolm Floyd (right knee) and rookie linebacker Manti Te’o (sprained right foot).
Corey Liuget left late in the first quarter with a shoulder injury. It was not immediately clear how it happened.