The Wayne County Sheriff’s Office says the accident occurred about 4 a.m. Thursday on Nebraska Highway 15 just north of Wayne.
The sheriff’s office says a southbound van driven by James Bauman, of Sioux City, Iowa, crossed into oncoming traffic and collided with the car driven by Joseph Ramirez.
Ramirez was pronounced dead at the scene. He was alone in his car.
The sheriff’s office says Bauman and his passenger, Nina Robertson, of Sioux City, Iowa, were taken to Providence Medical Center in Wayne.
The collision is being investigated.