The patrol says the crash occurred about 5 p.m. Friday on U.S. 85 north of Cheyenne when a southbound 1996 GMC Yukon crossed the center line and collided head-on with a northbound 2010 Chrysler Town and Country.
Two occupants in the Chrysler were killed. They were identified as 26-year-old Miguel Cruz and 29-year-old Selena Cruz, both of Lyman, Nebraska. They were both wearing seatbelts.
The driver of the GMC has been identified as 44-year-old Cheyenne resident Lila Mikesell, who was not wearing a seatbelt and also died.
The patrol says reckless driving and impairment are being investigated on the part of Mikesell as contributing factors.