The U.S. Attorney’s Office in Dallas released a statement saying most of the defendants are from northern Texas and would appear in court beginning Wednesday.
They face charges that include intent to distribute cocaine and methamphetamines, conspiracy and money laundering.
The indictment says undercover agents gave some suspects packages purporting to be drugs that were carried on flights to Chicago, San Francisco and other cities for payments of up to $9,000.
Authorities say four defendants either worked at Dallas-Fort Worth International Airport or used ties to an airport worker to bypass security.
It’s unclear how many defendants are in custody. The U.S. attorney’s office declined comment beyond its press release.